Different from other similar CPAP cleaners, the VirtuCLEAN does not have an essential Pre-wash. There is no requirement for any other disinfectants or sanitizers when you use the VirtuCLEAN unit. You will not need daily soap, water, or cleaning solutions. The VirtuClean utilizes the disinfecting process created by ozone, otherwise known as activated oxygen or O3. The O3 creates an environment that is 99% germ-free. If for some reason oil from your face and hair or any other residue were to get on your CPAP mask, you could use facial wipes or cleaners that were approved by your CPAP machine’s manufacturer.